World Health Organization Essential Medicines List: Multiple sclerosis disease-modifying therapies application.

The World Health Organization (WHO) publishes a biennial Essential Medicines List (EML) to assist governments in low-resource settings to prioritize their spending on medicines. Currently, no medicines on the EML have a multiple sclerosis (MS) indication. Multiple Sclerosis International Federation (MSIF) prepared an application for inclusion of MS disease-modifying therapies (DMTs) for the 2019 EML together with the regional Committees for Treatment and Research in Multiple Sclerosis (TRIMS) and the World Federation of Neurology. The MSIF taskforce categorized 15 DMTs according to their efficacy and risk profiles to ensure the ability to treat as many different clinical scenarios as possible. Three DMTs were selected: glatiramer acetate, fingolimod, and ocrelizumab. The WHO Expert Committee did not recommend the addition of any of the DMTs to the EML. They acknowledged the public health burden of MS, the need for effective and affordable MS medications, and the high volume of letters received in support of the application but requested a revised application. Despite the negative outcome, the repeated recognition of MS as a global public health burden is sending a powerful message to governments globally that a range of affordable and good quality medications need to be available to health systems and people affected by MS.

Citation

Jennifer McDonell, Kathleen Costello, Joanna Laurson-Doube, Nick Rijke, Gavin Giovannoni, Brenda Banwell, Peer Baneke. World Health Organization Essential Medicines List: Multiple sclerosis disease-modifying therapies application. Multiple sclerosis (Houndmills, Basingstoke, England). 2020 Feb;26(2):153-158

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PMID: 31944872

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