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Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types. Systemic toxicity with reflex on the central nervous and cardiovascular systems is their most feared adverse reactions, and the anaphylactic reaction is the most concerning one. Although potentially fatal, these events are extremely rare, so local anesthetics are considered safe for use in in-office procedures. Copyright © 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. All rights reserved.


Ana Carolina Figueiredo Pereira Cherobin, Glaysson Tassara Tavares. Safety of local anesthetics. Anais brasileiros de dermatologia. 2020 Jan - Feb;95(1):82-90

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PMID: 31952994

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