Modulation of the Somatosensory Blink Reflex in the Peripersonal Space Is Defective in Episodic Migraine.

In migraine, there is an altered behavior of patients during the attack and an altered connectivity in the cortical structures modulating and encoding the sensation and pain. Thus, we hypothesized that the extent of the peripersonal space (PPS) and the responses in the PPS may change during a migraine attack. For this reason, we analyzed the modulation of somatosensory blink reflex (SBR) in the PPS during episodic migraine. Cross-sectional assessment of modulation of SBR in patients with migraine. Headache outpatient clinic of a tertiary referral center. We included 22 patients with episodic migraine, of whom 13 individuals were in the interictal period and nine were experiencing a headache episode. We also included 14 healthy individuals. The three groups were similar in age and gender. SBR was recorded when the participants were sitting with their forearm in the extrapersonal space and also when their hands were in the PPS surrounding the face. Latency, amplitude, and area under the curve (AUC) were measured and compared. The amplitude and AUC of the SBR were significantly higher in patients during the attack compared with healthy subjects. The magnitude of the SBR was increased in the PPS in healthy subjects, whereas the increase was not significant in patients during the attack or in the interictal period. We think that the modulation in the PPS is defective in patients with migraine both during the acute attack and in the interictal phase, suggesting diminished top-down modulation of the SBR. © 2020 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Citation

Selahattin Ayas, Meral E Kızıltan, Feray Karaali-Savrun, Ayşegül Gündüz. Modulation of the Somatosensory Blink Reflex in the Peripersonal Space Is Defective in Episodic Migraine. Pain medicine (Malden, Mass.). 2020 Aug 01;21(8):1663-1667

Mesh Tags

PMID: 31958117

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