Correlation Engine 2.0
Clear Search sequence regions

  • colitis (2)
  • colon (2)
  • dextran (1)
  • female (1)
  • galanin (11)
  • galanin receptor (1)
  • galanin receptor (2)
  • GalR1 (1)
  • GalR2 (1)
  • gi tract (1)
  • mice (3)
  • sodium (1)
  • splanchnic nerve (3)
  • upper gi tract (1)
  • Sizes of these terms reflect their relevance to your search.

    Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the actions of galanin on colonic spinal afferent function. Specifically, we sought to evaluate the effect of galanin on lumbar splanchnic nerve (LSN) mechanosensitivity to noxious distending pressures and the development of hypersensitivity in the presence of inflammatory stimuli and colitis. Using ex vivo electrophysiological recordings we show that galanin produces a dose-dependent suppression of colonic LSN responses to mechanical stimuli and prevents the development of hypersensitivity to acutely administered inflammatory mediators. Using galanin receptor (GalR) agonists, we show that GalR1 activation, but not GalR2/3 activation, suppresses mechanosensitivity. The effect of galanin on colonic afferent activity was not observed in tissue from mice with dextran sodium sulfate-induced colitis. We conclude that galanin has a marked suppressive effect on colonic mechanosensitivity at noxious distending pressures and prevents the acute development of mechanical hypersensitivity to inflammatory mediators, an effect not seen in the inflamed colon. These actions highlight a potential role for galanin in the regulation of mechanical nociception in the bowel and the therapeutic potential of targeting galaninergic signaling to treat visceral hypersensitivity. © 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.


    Toni S Taylor, Parvesh Konda, Sarah S John, David C Bulmer, James R F Hockley, Ewan St John Smith. Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Physiological reports. 2020 Jan;8(2):e14326

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31960596

    View Full Text