Correlation Engine 2.0
Clear Search sequence regions

  • diagnosis (1)
  • gene (2)
  • homeostasis (1)
  • human (2)
  • mice (3)
  • nervous system (1)
  • parkinson disease (13)
  • patients (4)
  • protein control (1)
  • protein human (1)
  • rna (2)
  • valosin (2)
  • VCP (9)
  • Sizes of these terms reflect their relevance to your search.

    Valosin-containing human protein (VCP) or p97 performs enzyme functions associated with the maintenance of protein homeostasis and control of protein quality. Disruption of its normal functioning might be associated with the development of Parkinson's disease (PD). Tissues of mice with toxin-induced presymptomatic and early symptomatic stages of PD, as well as 52 treated and untreated patients with newly diagnosed PD and nine patients with a "predicted" form of PD, were investigated. Significant changes in Vcp gene expression were observed in almost all studied mouse tissues. A significant decrease in VCP expression specific for PD was also detected at both the late preclinical and the early clinical stages of PD in untreated patients. Thus, a decrease in VCP expression is important for changes in the function of the nervous system at early stages of PD. Analysis of changes in VCP expression in all patients with PD and in Vcp in the peripheral blood of mice used as models of PD revealed significant decreases in expression specific for PD. These data suggest that a decrease in the relative levels of VCP mRNA might serve as a biomarker for the development of pathology at the early clinical and preclinical stages of human PD.


    Anelya Alieva, Margarita Rudenok, Elena Filatova, Alexey Karabanov, Olga Doronina, Kseniya Doronina, Anna Kolacheva, Mikhail Ugrumov, Sergey Illarioshkin, Petr Slominsky, Maria Shadrina. VCP expression decrease as a biomarker of preclinical and early clinical stages of Parkinson's disease. Scientific reports. 2020 Jan 21;10(1):827

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31964996

    View Full Text