The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers.

Marco Toffoli, Laura Smith, Anthony H V Schapira

Journal of neurochemistry 2020 Jul

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The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding this disorder's pathophysiology and potential treatment. Among these genes, GBA1 is one of the most common and well-studied, but it is still unclear how mutations in GBA1 translate into an increased risk for developing PD. In this review, we provide an overview of the biochemical and structural relationship between GBA1 and PD to help understand the recent advances in the development of PD therapies intended to target this pathway. © 2020 International Society for Neurochemistry.

Citation

Marco Toffoli, Laura Smith, Anthony H V Schapira. The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers. Journal of neurochemistry. 2020 Jul;154(1):11-24