The emerging role of dipeptidyl-peptidase-4 as a therapeutic target in lung disease.

Hai Zou, Ning Zhu, Shengqing Li

Expert opinion on therapeutic targets 2020 Feb

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Introduction: Dipeptidyl-peptidase-4 (DPP-4) is a surface bound ectopeptidase that is commonly known as CD26 or adenosine deaminase binding protein. DPP-4 is membrane anchored but it can be cleaved by numerous proteases including matrix-metalloproteinases (MMPs). DPP-4 is expressed by endothelial and epithelial cells, the kidney, intestine and cells of the immune system; it has a broad spectrum of biological functions in immune regulation, cancer biology and glucose metabolism.Areas covered: This article sheds light on the functions of DPP-4, the molecular mechanisms that govern its expression, it's role in the pathogenesis of common respiratory illnesses and potential as a therapeutic target.Expert opinion: DPP-4 has a deleterious role in respiratory disease. Its biological functions, key molecular pathways, interactions and associations are slowly being elucidated. Progressing our knowledge of the role of this multi-faceted molecule may yield vital and novel therapies for respiratory diseases such as lung cancer, asthma, and chronic obstructive pulmonary disease (COPD).

Citation

Hai Zou, Ning Zhu, Shengqing Li. The emerging role of dipeptidyl-peptidase-4 as a therapeutic target in lung disease. Expert opinion on therapeutic targets. 2020 Feb;24(2):147-153