Isoxazole-containing 5' mRNA cap analogues as inhibitors of the translation initiation process.

Karolina Piecyk, Maciej Lukaszewicz, Karol Kamel, Maria Janowska, Paulina Pietrow, Sebastian Kmiecik, Marzena Jankowska-Anyszka

Bioorganic chemistry 2020 Mar

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Herein we describe a synthesis of new isoxazole-containing 5' mRNA cap analogues via a cycloaddition reaction. The obtained analogues show a capability to inhibit cap-dependent translation in vitro and are characterized by a new binding mode in which an isoxazolic ring, instead of guanine, is involved in the stacking effect. Our study provides valuable information toward designing new compounds that can be potentially used as anticancer therapeutics. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Karolina Piecyk, Maciej Lukaszewicz, Karol Kamel, Maria Janowska, Paulina Pietrow, Sebastian Kmiecik, Marzena Jankowska-Anyszka. Isoxazole-containing 5' mRNA cap analogues as inhibitors of the translation initiation process. Bioorganic chemistry. 2020 Mar;96:103583