Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease.

Udaysankar Chockanathan, Emily J Warner, Loel Turpin, M Kerry O'Banion, Krishnan Padmanabhan

Scientific reports 2020 Jan 23

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While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer's disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population's coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation causes to the computations performed by neural circuits.

Citation

Udaysankar Chockanathan, Emily J Warner, Loel Turpin, M Kerry O'Banion, Krishnan Padmanabhan. Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease. Scientific reports. 2020 Jan 23;10(1):1077