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The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts. Copyright © 2020 Elsevier Ltd. All rights reserved.


Nadine Martin, Olivier Soriani, David Bernard. Cardiac Glycosides as Senolytic Compounds. Trends in molecular medicine. 2020 Mar;26(3):243-245

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PMID: 31983612

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