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To estimate an accurate level of IL-8 in aqueous humor among open-angle glaucoma (OAG) patients. Meta-analysis was performed from available studies that investigated the IL-8 level in the aqueous humor of OAG patients and control subjects. A total of 17 studies were selected. The pooled result showed that IL-8 levels in aqueous humor of patients with OAG were higher than in control subjects (SMD=0.98, 95% CI=0.68-1.27, p<0.00001). This meta-analysis indicates that patients with OAG may have a higher aqueous humor IL-8 levels compared to control subjects, which supports the notion that IL-8 is one of the contributing factors in the development of OAG. Copyright © 2019 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.


Z S Ulhaq. Chemokine IL-8 level in aqueous humor of open-angle glaucoma: A meta-analysis. Archivos de la Sociedad Espanola de Oftalmologia. 2020 Mar;95(3):114-119

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PMID: 31987603

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