Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans.

María Carolina Amezcua Vesely, Constanza Rodríguez, Adriana Gruppi, Eva Virginia Acosta Rodríguez

Biochimica et biophysica acta. Molecular basis of disease 2020 May 01

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Host resistance during infection with Trypanosoma cruzi, and other protozoans, is dependent on a balanced immune response. Robust immunity against these pathogens requires of the concerted action of many innate and adaptive cell populations including macrophages, neutrophils, dendritic cells, CD4+, and CD8+ T cells and B cells among others. Indeed, during most protozoan infections only a balanced production of inflammatory (TH1) and anti-inflammatory (TH2/regulatory) cytokines will allow the control of parasite spreading without compromising host tissue integrity. The description of TH17 cells, a novel effector helper T cell lineage that produced IL-17 as signature cytokine, prompted the revision of our knowledge about the mechanisms that mediate protection and immunopathology during protozoan infections. In this manuscript we discuss the general features of IL-17 mediated immune responses as well as the cellular sources, effector mechanisms and overall role of IL-17 in the immune response to T. cruzi and other protozoan infections. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

María Carolina Amezcua Vesely, Constanza Rodríguez, Adriana Gruppi, Eva Virginia Acosta Rodríguez. Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans. Biochimica et biophysica acta. Molecular basis of disease. 2020 May 01;1866(5):165706