Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation.

Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation. © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

Citation

Anne-Claire Jacomin, Ioannis P Nezis. Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation. Molecular & cellular oncology. 2020;7(1):1682309

PMID: 31993495

search → result