Natural Products as a Paradigm for the Treatment of Coxsackievirus - induced Myocarditis.

Madhu Khanna, Anju Gautam, Roopali Rajput, Latika Sharma

Current topics in medicinal chemistry 2020

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Coxsackievirus B3 (CVB3), a member of the Picornaviridae family, is considered to be one of the most important infectious agents to cause virus-induced myocarditis. Despite improvements in studying viral pathology, structure and molecular biology, as well as diagnosis of this disease, there is still no virus-specific drug in clinical use. Structural and nonstructural proteins produced during the coxsackievirus life cycle have been identified as potential targets for blocking viral replication at the step of attachment, entry, uncoating, RNA and protein synthesis by synthetic or natural compounds. Moreover, WIN (for Winthrop) compounds and application of nucleic-acid based strategies were shown to target viral capsid, entry and viral proteases, but have not reached to the clinical trials as a successful antiviral agent. There is an urgent need for diverse molecular libraries for phenotype-selective and high-throughput screening. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Madhu Khanna, Anju Gautam, Roopali Rajput, Latika Sharma. Natural Products as a Paradigm for the Treatment of Coxsackievirus - induced Myocarditis. Current topics in medicinal chemistry. 2020;20(8):607-616