Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function.

Fiamma Salerno, Martin Turner, Monika C Wolkers

Trends in immunology 2020 Mar

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Effective T cell responses against infections and tumors require a swift and ample production of cytokines, chemokines, and cytotoxic molecules. The production of these effector molecules relies on rapid changes of gene expression, determined by cell-intrinsic signals and environmental cues. Here, we review our current understanding of gene-specific regulatory networks that define the magnitude and timing of cytokine production in CD8+ T cells. We discuss the dynamic features of post-transcriptional control during CD8+ T cell homeostasis and activation, and focus on the crosstalk between cell signaling and RNA-binding proteins. Elucidating gene-specific regulatory circuits may help in the future to rectify dysfunctional T cell responses. Copyright © 2020. Published by Elsevier Ltd.

Citation

Fiamma Salerno, Martin Turner, Monika C Wolkers. Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function. Trends in immunology. 2020 Mar;41(3):240-254