Correlation Engine 2.0
Clear Search sequence regions

  • birth (1)
  • c57bl mice (1)
  • dax 1 orphan nuclear receptor (2)
  • Dax1 (5)
  • female (1)
  • gene (2)
  • humans (1)
  • live birth (2)
  • mice (9)
  • mice knockout (1)
  • Nr0b1 (1)
  • nuclear receptor (2)
  • phenotypes (2)
  • processes (1)
  • sex (8)
  • Sry (2)
  • testis (1)
  • Y Protein (2)
  • Sizes of these terms reflect their relevance to your search.

    The nuclear hormone receptor Dax1 functions during development as a testes-determining gene. However, the phenotype of male mice lacking Dax1 is strain-dependent due to the background-specific abundance of male-determining Sry gene-transcripts. We hypothesised that inter-individual variation in Sry mRNA-abundance would result in a spectrum of phenotypes even within-strain. We found that while all XY C57BL/6J mice lacking Dax1 presented as phenotypic females, there was a marked inter-individual variability in measures of fertility. Indeed, we report rare occasions where sex-reversed mice had measures of fertility comparable to those in control females. On two occasions, these sex-reversed XY mice were able to give birth to live offspring following mating to stud-males. As such, this work documents within-strain variability in phenotypes of XY mice lacking Dax1, and reports for the first time a complete sex-reversal capable of achieving live birth in these mice.


    Isabel Fernandes-Freitas, Alexandra Milona, Kevin G Murphy, Waljit S Dhillo, Bryn M Owen. Live Birth in Sex-Reversed XY Mice Lacking the Nuclear Receptor Dax1. Scientific reports. 2020 Feb 03;10(1):1703

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32015477

    View Full Text