Correlation Engine 2.0
Clear Search sequence regions

  • biosynthesis (1)
  • CYP2 (1)
  • CYP3 (1)
  • CYP4 (1)
  • enzymes (1)
  • family (6)
  • gene (2)
  • heme- proteins (1)
  • locust (2)
  • locusta migratoria (3)
  • monooxygenases (17)
  • P 450 (2)
  • P450s (17)
  • plant (2)
  • Sizes of these terms reflect their relevance to your search.

    Cytochrome P450 monooxygenases (P450s) constitute a large superfamily of heme-thiolate proteins that are involved in the biosynthesis or degradation of endogenous compounds and detoxification of exogenous chemicals. It has been reported that P450s could serve as odorant-degrading enzymes (ODEs) to inactivate odorants to avoid saturating the antennae. However, there is little information about P450s in the antennae of Locusta migratoria. In the current work, we conducted an antenna transcriptome analysis and identified 92 P450s, including 68 full-length and 24 partial sequences. Phylogenetic analysis showed that 68 full-length P450s were grouped into four clans: CYP2, CYP3, CYP4, and mitochondria clans. Tissue, stage, and sex-dependent expressions of these 68 P450s were investigated. The results showed that 4 P450s were antenna-specific, whereas others were antenna-rich but also expressed in other tissues, implying their various potential roles in the antennae. In addition, the responses of seven selected P450s to five gramineous plant volatiles and four locust volatiles were determined. CYP6MU1 could be induced by almost all compounds tested, suggesting its important roles in odorant processing. Different P450s exhibited diverse responses to odorants, indicating that specific regulation of P450 expression by odorants might modulate the sensitivity of the olfactory responses to various chemicals. Copyright © 2020 Elsevier B.V. All rights reserved.


    Haihua Wu, Yongmei Liu, Xuekai Shi, Xueyao Zhang, Changlü Ye, Kun Yan Zhu, Fang Zhu, Jianzhen Zhang, Enbo Ma. Transcriptome analysis of antennal cytochrome P450s and their transcriptional responses to plant and locust volatiles in Locusta migratoria. International journal of biological macromolecules. 2020 Apr 15;149:741-753

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32018005

    View Full Text