Double Trouble: Concomitant RB1 and BRCA2 Depletion Evokes Aggressive Phenotypes.

Amy C Mandigo, Karen E Knudsen

Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Apr 15

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Coordinate single- or two copy loss of the BRCA2/RB1 tumor suppressor genes, which reside in close chromosomal proximity, were found to be associated with aggressive prostate cancer and therapeutic resistance. Modeling these events and analyses of human cancers suggest that dual depletion of BRCA2/RB1 may represent a distinct subtype of disease.See related article by Chakraborty et al., p. 2047. ©2020 American Association for Cancer Research.

Citation

Amy C Mandigo, Karen E Knudsen. Double Trouble: Concomitant RB1 and BRCA2 Depletion Evokes Aggressive Phenotypes. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Apr 15;26(8):1784-1786