Spontaneous bilateral haemothorax with haemopericardium secondary to rivaroxaban.

Although the risk of major bleeding with non-vitamin K antagonist oral anticoagulant (NOAC) is low, life-threatening bleeding can occur. We report a case of an 81-year-old female with deep vein thrombosis who developed bilateral spontaneous haemothorax and haemopericardium after rivaroxaban therapy. Diagnostic thoracentesis revealed a grossly bloody pleural effusion. She was treated with factor eight inhibitor bypassing agent, but the result was not satisfactory. To our knowledge, this is the first case report of a concomitant presentation of spontaneous bilateral haemothorax and haemopericardium due to rivaroxaban use. This case highlights the potential risk of major haemorrhagic complication of NOAC, which could be life-threatening and require emergent reversal. © 2020 John Wiley & Sons Ltd.

Citation

Jiun-Hao Yu, Hao-Hsuan Liu, Ming-Jer Hsieh, I-Chang Hsieh, Pao-Hsien Chu, Dong-Yi Chen. Spontaneous bilateral haemothorax with haemopericardium secondary to rivaroxaban. Journal of clinical pharmacy and therapeutics. 2020 Oct;45(5):1175-1178

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PMID: 32023350

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