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Two new benzoic acid derivatives (1-2), together with four known compounds (3-6) have been isolated from the n-BuOH soluble fraction of ethanolic extract from Ailanthus altissima. The gross structures of the new compounds were deduced by detailed spectroscopic analysis including HRESIMS and 1D/2D NMR spectroscopy. The stereochemistry of 1 was determined by modified Mosher's method. All compounds were evaluated for their neuroprotective effects against H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells and none of them displayed obvious neuroprotective activities. [Formula: see text].


Ye-Qing Du, Zhi-Yang Yan, Shao-Chun Shi, Zi-Lin Hou, Xiao-Xiao Huang, Shao-Jiang Song. Benzoic acid derivatives from the root barks of Ailanthus altissima. Journal of Asian natural products research. 2021 Feb;23(2):103-109

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PMID: 32024382

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