Subtelomeric Transcription and its Regulation.

Marta Kwapisz, Antonin Morillon

Journal of molecular biology 2020 Jul 10

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The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal subtelomeric regions produce non-coding transcripts i.e., ARRET, αARRET, subTERRA, and TERRA, which function in telomere maintenance. The role and molecular mechanisms of the majority of subtelomeric transcripts remain unknown. This review depicts the current knowledge and puts into perspective the results obtained in different models from yeasts to humans. Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.