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    As ubiquitous environmental pollutants, phenolic compounds are requested to be efficiently removed from wastewater. Enzymes, such as Horseradish peroxidase (HRP), have been demonstrated with great potential in removing phenolic compounds. Different from the general immobilization technology, the encapsulation of individual enzymes within nanogel has been employed in this work. Here we show that, the encapsulated HRP could remarkably enhance enzymatic performance, including thermostability, catalytic efficiency, environmental tolerance and, most importantly, the biodegradation of phenolic compounds. For instance, the removal efficiencies of phenol and BPA increased by 7-fold and 3.5-fold, respectively. On the other hand, the diverted removal efficiencies were obtained for a series of phenolic compounds. Based on molecular modelling, the biodegradabilities of phenolic compounds were rationalized according to their redox potentials and binding affinities with enzymes. In summary, our work indicates that the nanocapsulation of enzyme should be a promising strategy in removing different types of phenolic compounds from wastewater. Copyright © 2020 Elsevier B.V. All rights reserved.


    Shan Liu, Biyan Huang, Guiqin Zheng, Peng Zhang, Juying Li, Bo Yang, Yantao Chen, Li Liang. Nanocapsulation of horseradish peroxidase (HRP) enhances enzymatic performance in removing phenolic compounds. International journal of biological macromolecules. 2020 May 01;150:814-822

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    PMID: 32035963

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