Centromere chromatin structure - Lessons from neocentromeres.

Catherine Naughton, Nick Gilbert

Experimental cell research 2020 Apr 15

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Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Catherine Naughton, Nick Gilbert. Centromere chromatin structure - Lessons from neocentromeres. Experimental cell research. 2020 Apr 15;389(2):111899