Circular RNA-ITCH Inhibits the Proliferation of Ovarian Carcinoma by Downregulating lncRNA HULC.

Hua Yan, Haiyun Xiang, Bingmei Sun, Fuzhong Feng, Ping Chen

Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan

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Circular RNA-ITCH has been proven to be tumor suppressor in esophageal and lung cancer, while the role of this RNA in other types of cancers is unknown. In this study, we observed that circular RNA-ITCH was downregulated, while lncRNA HULC was upregulated in ovarian carcinoma. Circular RNA-ITCH and HULC were inversely and significantly correlated. Overexpression of circular RNA-ITCH resulted in inhibited, while overexpression of HULC promoted the proliferation of cells of ovarian cancer cell lines. Overexpression of circular RNA-ITCH led to inhibited HULC in cells of ovarian cancer cell lines, while overexpression of HULC failed to significantly affect the expression of circular RNA-ITCH but attenuated the inhibitory effects of circular RNA-ITCH overexpression. However, overexpression of circular RNA-ITCH failed to affect cancer cell behaviors. Therefore, circular RNA-ITCH may inhibit the proliferation of ovarian carcinoma by downregulating HULC.

Citation

Hua Yan, Haiyun Xiang, Bingmei Sun, Fuzhong Feng, Ping Chen. Circular RNA-ITCH Inhibits the Proliferation of Ovarian Carcinoma by Downregulating lncRNA HULC. Reproductive sciences (Thousand Oaks, Calif.). 2020 Jan;27(1):375-379