Expression of fucosylated glycans in endothelial glycocalyces of placental villi at early and late fetal growth restriction.
M M Ziganshina, G V Kulikova, N M Fayzullina, E L Yarotskaya, A I Shchegolev, Jacques Le Pendu, Adrien Breiman, N V Shilova, N R Khasbiullina, N V Bovin, N E Kan, V L Tyutyunnik, Z S Khodzhaeva, G T Sukhikh
Placenta 2020 Jan 15The aim of the study was to investigate the content and distribution of fucosylated sugar residues and Lewis Y (LeY) in the endothelial glycocalyx (eGC) in placental tissue at early and late onset fetal growth restriction (FGR). Our findings demonstrated that the changes of the fucosylated glycans of type 2 (H2)/LeY in the vascular endothelium of the villi may reflect alteration of villi maturation, or adaptation to hypoxia through the change of cell proliferation potential and induction angiogenesis. Early onset FGR differs from late onset FGR by a markedly increased LeY expression, being associated with more severe pathological state. Copyright © 2019 Elsevier Ltd. All rights reserved.
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M M Ziganshina, G V Kulikova, N M Fayzullina, E L Yarotskaya, A I Shchegolev, Jacques Le Pendu, Adrien Breiman, N V Shilova, N R Khasbiullina, N V Bovin, N E Kan, V L Tyutyunnik, Z S Khodzhaeva, G T Sukhikh. Expression of fucosylated glycans in endothelial glycocalyces of placental villi at early and late fetal growth restriction. Placenta. 2020 Jan 15;90:98-102
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PMID: 32056559
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