Dihydro-β-agarofuran sesquiterpenoid derivatives with neuroprotective activity from the leaves of Tripterygium wilfordii.

Peng Zhao, Bin Lin, Zi-Lin Hou, Le Zhou, Qing-Jun He, Guo-Dong Yao, Xiao-Xiao Huang, Shao-Jiang Song

Fitoterapia 2020 Apr

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A phytochemical investigation on the leaves of Tripterygium wilfordii Hook. F. was conducted, leading to the isolation of five undescribed dihydro-β-agarofuran sesquiterpenoids (1-5) and one known analogue (6). Their structures were determined by comprehensive spectroscopic analyses. The absolute configurations of the compounds were determined by comparison of the experimental ECD with the calculated data. In addition, all the compounds were evaluated for their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells, and 3 showed the better protective effect with 76.63% cell viability comparing with the positive control Trolox (69.84%) at 12.5 μM. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Peng Zhao, Bin Lin, Zi-Lin Hou, Le Zhou, Qing-Jun He, Guo-Dong Yao, Xiao-Xiao Huang, Shao-Jiang Song. Dihydro-β-agarofuran sesquiterpenoid derivatives with neuroprotective activity from the leaves of Tripterygium wilfordii. Fitoterapia. 2020 Apr;142:104501