Fabrication of a novel drug-resin combination device for controlled release of dextromethorphan hydrobromide.

Haofan Liu, Liandong Hu, Rahul Pratap Singh, Brijesh Dave, Jiawei Chen, Jiaojiao Yu

Colloids and surfaces. B, Biointerfaces 2020 May

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The implimentation of newer technologies in drug delivery system have always been the focus of pharmaceutical scientists with advancement of technologies. In this investigation, a novel controlled-release drug-resin combination device (DRC) was designed using dental resin to control the release of dextromethorphan hydrobromide (DH). The influence of different factors on in-vitro drug release were investigated. A Box-Behnken design was used to select the optimized DRC formulation. The optimized DH loaded DRC (DH-DRC) was prepared using 59.88% of PEG400, 16 mg of dental resin and 6.64 mg of sodium chloride (NaCl). The DH releases at 2 h, 4 h and 8 h of the optimized formulation were significantly close to the predicted responses. The pharmacokinetic study in rabbits showed DH-DRC had prolonged tmax and apparently reduced Cmax compared with commercial tablets and the AUC0-24h of DH-DRC was slightly higher than commercial tablets. This study confirmed the novel DRC could control the release of drug. It concluded that DRC would be a promising and alternative approach for the development of controlled release dosage form. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Haofan Liu, Liandong Hu, Rahul Pratap Singh, Brijesh Dave, Jiawei Chen, Jiaojiao Yu. Fabrication of a novel drug-resin combination device for controlled release of dextromethorphan hydrobromide. Colloids and surfaces. B, Biointerfaces. 2020 May;189:110833