Methoxsalen-induced advanced bull's eye maculopathy.

Ratnesh Ranjan, George J Manayath, Romit Salian, Venkatapathy Narendran

European journal of ophthalmology 2021 May

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A number of systemic medications are known to cause macular toxicity, and bull's eye maculopathy is caused by some of them like hydroxychloroquine and clofazimine. A 55-year-old female, known case of vitiligo with history of undergoing methoxsalen-ultraviolet A therapy, presented with painless defective vision in both eyes. Fundus examination and autofluorescence showed macular degeneration with bull's eye configuration. Optical coherence tomography showed perifoveal loss of photoreceptors and outer retinal thinning with foveal sparing appearing as 'flying saucer'. Multifocal electroretinogram showed pan-macular suppression of waveforms. Patient was diagnosed as case of methoxsalen-induced advanced macular toxicity. This is the first reported case of methoxsalen-induced advanced bull's eye maculopathy.

Citation

Ratnesh Ranjan, George J Manayath, Romit Salian, Venkatapathy Narendran. Methoxsalen-induced advanced bull's eye maculopathy. European journal of ophthalmology. 2021 May;31(3):NP70-NP73