Adiponectin in renal fibrosis.

Huan Jing, Simin Tang, Sen Lin, Meijuan Liao, Hongtao Chen, Youling Fan, Jun Zhou

Aging 2020 Feb 17

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Renal fibrosis is an inevitable consequence of parenchymal scarring and is the common final pathway that mediates almost all progressive renal diseases. Adiponectin, a hormone produced by adipose tissue, possesses potent anti-insulin, anti-inflammatory, and anti-fibrotic properties. Reportedly, adiponectin serves as an important messenger that facilitates complex interactions between adipose tissue and other metabolically related organs. In recent years, a growing body of evidence supports adiponectin involvement in renal fibrosis. These studies provide a deeper understanding of the molecular mechanism of action of adiponectin in renal fibrosis and also offer a potential preventive and therapeutic target for renal fibrosis. In this review, the physiological role of adiponectin is briefly introduced, and then the mechanism of adiponectin-mediated renal fibrosis and the related signaling pathways are described. Finally, we summarize the findings regarding the clinical value of adiponectin in renal fibrotic diseases and prospected its application potential.

Citation

Huan Jing, Simin Tang, Sen Lin, Meijuan Liao, Hongtao Chen, Youling Fan, Jun Zhou. Adiponectin in renal fibrosis. Aging. 2020 Feb 17;12(5):4660-4672