The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia.

Jinjing Zhang, Yue Wang, Wenbin Mo, Rui Zhang, Yan Li

International journal of laboratory hematology 2020 Jun

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The expression of forkhead box N3 (FOXN3), also known as checkpoint suppressor 1 (CHES1), is reduced in many types of tumours. However, the clinical significance of FOXN3 and its potential role in acute myeloid leukaemia (AML) remain largely unknown. A total of 117 de novo AML patients newly diagnosed between December 2015 and January 2018 were included in this study. The expression of FOXN3 and its clinical significance were analysed in these AML patients. The expression of FOXN3 was significantly downregulated in AML. In addition, lower FOXN3 expression was associated with older age and higher white blood cell counts. Moreover, a close correlation was observed between lower FOXN3 expression and a lower complete remission (CR) rate and shorter overall survival (OS), which was further analysed by multivariate analysis. These data suggest that FOXN3 is a novel biomarker in AML and that lower FOXN3 expression predicts poor chemotherapy response and prognosis in AML. © 2020 The Authors. International Journal of Laboratory Hematology published by John Wiley & Sons Ltd.

Citation

Jinjing Zhang, Yue Wang, Wenbin Mo, Rui Zhang, Yan Li. The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia. International journal of laboratory hematology. 2020 Jun;42(3):270-276