Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats.

Dietary protein and amino acid intake and composition can modulate immune function. To evaluate the effects of high-protein intake and arginine and ornithine supplementation on feline immune cells. Ten healthy cats. Experimental study. Cats received a high-protein basal diet as a single daily meal. A crossover design was applied with treatments being basal diet (w/o); basal diet with arginine supplementation (+50, 75, 100% compared to the arginine provision by the basal diet; Arg 1-3); and basal diet with ornithine supplementation (+100, 150, 200% compared to the arginine provision by the basal diet; Orn 1-3). Blood samples were collected at the end of each 11-day treatment period. Mitogen-stimulated proliferative activity of blood leukocytes revealed a quadratic effect for the dietary supplementation of arginine (P = .02) and ornithine (P = .03) (means for ConA-stimulation: w/o = 6.96; Arg 1 = 9.31; Arg 2 = 11.4; Arg 3 = 8.04; Orn 1 = 15.4; Orn 2 = 9.43; Orn 3 = 9.28; pooled SEM: 0.96). The number (% gated) of phagocytic granulocytes linearly decreased with increasing dietary concentrations of arginine (P = .05) and ornithine (P = .03) (means: w/o = 95.5; Arg 1 = 93.0; Arg 2 = 92.5; Arg 3 = 92.6; Orn 1 = 92.6; Orn 2 = 92.6; Orn 3 = 91.5; pooled SEM = 0.44). This study could demonstrate immunomodulating properties of dietary arginine and ornithine in cats. © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

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Nadine Paßlack, Barbara Kohn, Jürgen Zentek. Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats. Journal of veterinary internal medicine. 2020 Mar;34(2):852-856

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PMID: 32086838

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