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The acquisition of mutations in hematologic stem cells (clonal hematopoiesis) is common with normal aging and can be identified as an incidental finding through clinical genetic testing. Clonal hematopoiesis is associated with a heightened risk of developing hematologic neoplasms (especially myeloid) and accelerated atherosclerotic cardiovascular disease. This article discusses a multidisciplinary clinical approach to the management of patients with clonal hematopoiesis. Key areas of research needed to establish evidence-based clinical care guidelines and intervention strategies for individuals with clonal hematopoiesis are discussed. Copyright © 2019 Elsevier Inc. All rights reserved.


Kelly L Bolton, Ahmet Zehir, Ryan N Ptashkin, Minal Patel, Dipti Gupta, Robert Sidlow, Elli Papaemmanuil, Michael F Berger, Ross L Levine. The Clinical Management of Clonal Hematopoiesis: Creation of a Clonal Hematopoiesis Clinic. Hematology/oncology clinics of North America. 2020 Apr;34(2):357-367

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PMID: 32089215

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