MCMs in Cancer: Prognostic Potential and Mechanisms.

Si Yu, Guanqun Wang, Yue Shi, Haifeng Xu, Yongchang Zheng, Yang Chen

Analytical cellular pathology (Amsterdam) 2020

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Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells. Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication initiation and play vital roles in controlling replication times within a cell cycle. Overexpressed MCMs are detected in various cancerous tissues and cancer cell lines. Previous studies have proposed MCMs as promising proliferation markers in cancers, while the prognostic values remain controversial and the underlying mechanisms remain unascertained. This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family. Besides, current evidence of the prognostic roles of MCMs is retrospectively reviewed. This work also offers insight into the mechanisms of MCMs prompting carcinogenesis and adverse prognosis, providing information for future research. Finally, MCMs in liver cancer are specifically discussed, and future perspectives are provided. Copyright © 2020 Si Yu et al.

Citation

Si Yu, Guanqun Wang, Yue Shi, Haifeng Xu, Yongchang Zheng, Yang Chen. MCMs in Cancer: Prognostic Potential and Mechanisms. Analytical cellular pathology (Amsterdam). 2020;2020:3750294