Dissecting the signaling pathways involved in the function of sperm flagellum.

Lenka Vyklicka, Polina V Lishko

Current opinion in cell biology 2020 Apr

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The mammalian flagellum is a specific type of motile cilium required for sperm motility and male fertility. Effective flagellar movement is dependent on axonemal function, which in turn relies on proper ion homeostasis within the flagellar compartment. This ion homeostasis is maintained by the concerted function of ion channels and transporters that initiate signal transduction pathways resulting in motility changes. Advances in electrophysiology and super-resolution microscopy have helped to identify and characterize new regulatory modalities of the mammalian flagellum. Here, we discuss what is currently known about the regulation of flagellar ion channels and transporters that maintain sodium, potassium, calcium, and proton homeostasis. Identification of new regulatory elements and their specific roles in sperm motility is imperative for improving diagnostics of male infertility. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Lenka Vyklicka, Polina V Lishko. Dissecting the signaling pathways involved in the function of sperm flagellum. Current opinion in cell biology. 2020 Apr;63:154-161