Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors.

Nidhi Mishra, Anand K Agrahari, Priyanka Bose, Sumit K Singh, Anoop S Singh, Vinod K Tiwari

Scientific reports 2020 Feb 27

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Among all the malaria parasites, P. falciparum is the most predominant species which has developed drug resistance against most of the commercial anti-malarial drugs. Thus, finding a new molecule for the inhibition of enzymes of P. falciparum is the pharmacological challenge in present era. Herein, ten novel molecules have been designed with an amalgamation of cinchonidine, carbohydrate moiety and triazole ring by utilizing copper-catalyzed click reaction of cinchonidine-derived azide and clickable glycosyl alkynes. The molecular docking of developed molecules showed promising results for plasmepsin inhibition in the form of effective binding with target proteins.

Citation

Nidhi Mishra, Anand K Agrahari, Priyanka Bose, Sumit K Singh, Anoop S Singh, Vinod K Tiwari. Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors. Scientific reports. 2020 Feb 27;10(1):3586