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Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme-a highly reactive and inherently toxic compound-and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria.


Samantha A Swenson, Courtney M Moore, Jason R Marcero, Amy E Medlock, Amit R Reddi, Oleh Khalimonchuk. From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme. Cells. 2020 Feb 29;9(3)

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PMID: 32121449

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