Sylvain Darnet, Laetitia B B Martin, Pierre Mercier, Franz Bracher, Philippe Geoffroy, Hubert Schaller
Molecules (Basel, Switzerland) 2020 Mar 02Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.
Sylvain Darnet, Laetitia B B Martin, Pierre Mercier, Franz Bracher, Philippe Geoffroy, Hubert Schaller. Inhibition of Phytosterol Biosynthesis by Azasterols. Molecules (Basel, Switzerland). 2020 Mar 02;25(5)
PMID: 32131509
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