A key control point in the T cell response to chronic infection and neoplasia: FOXO1.

Nimi Marcel, Stephen M Hedrick

Current opinion in immunology 2020 Apr

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T cells able to control neoplasia or chronic infections display a signature gene expression profile similar or identical to that of central memory T cells. These cells have qualities of self-renewal and a plasticity that allow them to repeatedly undergo activation (growth, proliferation, and differentiation), followed by quiescence. It is these qualities that define the ability of T cells to establish an equilibrium with chronic infectious agents, and also preserve the ability of T cells to be re-activated (by checkpoint therapy) in response to malignant cancers. Here we describe distinctions between the forms of inhibition mediated by tumors and persistent viruses, we review the properties of T cells associated with long-term immunity, and we identify the transcription factor, FOXO1, as the control point for a program of gene expression that allows CD8+ T cells to undergo serial reactivation and self-renewal. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Nimi Marcel, Stephen M Hedrick. A key control point in the T cell response to chronic infection and neoplasia: FOXO1. Current opinion in immunology. 2020 Apr;63:51-60