Metabolomic approach for rapid differentiation of Fritillaria bulbs by matrix-assisted laser desorption/ionization mass spectrometry and multivariate statistical analysis.

Ze Wang, Hanyi Xie, Juan Ren, Yang Chen, Xiaofei Li, Xiangfeng Chen, Tak-Wah Dominic Chan

Journal of pharmaceutical and biomedical analysis 2020 Jun 05

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The bulbs of Fritillaria have been used for centuries as food and medicinal products in many Asian countries. Different Fritillaria species have distinct pharmacological effects despite of their similar appearances. Effective differentiation of Fritillaria species can avoid adulteration and is crucial to its clinical uses. In this paper, a hybrid method of matrix assisted laser desorption/ionization mass spectrometry and multivariate statistical analysis was developed for the rapid and reliable differentiation of Fritillaria species for the first time. Significantly different patterns for five Fritillaria species were obtained by MALDI-MS after instant sample extractions. Different groups of Fritillaria were confidently differentiated via an orthogonal partial least square model. In addition, a metabolomic taxonomy of five Fritillaria species was obtained based on MALDI-MS data. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Ze Wang, Hanyi Xie, Juan Ren, Yang Chen, Xiaofei Li, Xiangfeng Chen, Tak-Wah Dominic Chan. Metabolomic approach for rapid differentiation of Fritillaria bulbs by matrix-assisted laser desorption/ionization mass spectrometry and multivariate statistical analysis. Journal of pharmaceutical and biomedical analysis. 2020 Jun 05;185:113177