Correlation Engine 2.0
Clear Search sequence regions


  • acid (4)
  • adduct (1)
  • amino acid (1)
  • antibiotics (4)
  • appear (2)
  • behavior (1)
  • beta lactam (15)
  • beta lactamases (47)
  • boron (2)
  • ca 10 (1)
  • CARB (2)
  • carbapenems (6)
  • carbon (2)
  • catalysis (1)
  • cephalosporins (3)
  • crystal (1)
  • CTX M- 15 (5)
  • d enzymes (3)
  • donors (3)
  • enzymes (20)
  • equilibrium (1)
  • gram (1)
  • hydrogen bond (2)
  • hydrolysis (2)
  • imipenem (6)
  • inhibit (11)
  • inhibitor enzymes (1)
  • jump (2)
  • MBLs (15)
  • meropenem (2)
  • monobactams (2)
  • nitrocefin (18)
  • oxa (7)
  • penicillins (3)
  • profiles (9)
  • protect (1)
  • reason (1)
  • sodium phosphate (1)
  • stenotrophomonas maltophilia (1)
  • suggests (1)
  • sulbactam (1)
  • tazobactam (2)
  • TEM 1 (1)
  • v e (1)
  • Sizes of these terms reflect their relevance to your search.

    QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam. The spectrum and mechanism of beta-lactamase inhibition by QPX7728 were assessed using purified enzymes from all molecular classes. QPX7728 inhibits class A extended-spectrum beta-lactamases (ESBLs) (50% inhibitory concentration [IC50] range, 1 to 3 nM) and carbapenemases such as KPC (IC50, 2.9 ± 0.)

    Citation

    Ruslan Tsivkovski, Maxim Totrov, Olga Lomovskaya. Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases Antimicrobial Agents and Chemotherapy. 2020 May 21;64(6)


    PMID: 32152086

    View Full Text