Asprosin: A Novel Player in Metabolic Diseases.

Mingyang Yuan, Weidong Li, Yan Zhu, Boyao Yu, Jing Wu

Frontiers in endocrinology 2020

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Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue during fasting. Asprosin plays a complex role in the central nervous system (CNS), peripheral tissues, and organs. It is involved in appetite, glucose metabolism, insulin resistance (IR), cell apoptosis, etc. In this review, we will summarize the newly discovered roles of asprosin in metabolic diseases including diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD), which may contribute to future clinical diagnosis and treatment. Copyright © 2020 Yuan, Li, Zhu, Yu and Wu.