A master regulator of cholesterol biosynthesis constitutes a therapeutic liability of triple negative breast cancer.

Lipid and cholesterol reprogramming are often observed in specific cancer subtypes. We find that triple-negative breast cancers (TNBCs), but not estrogen receptor-positive (ER+) ones, adopt nuclear receptor RAR-related orphan receptor γ (RORγ) as their new master activator of cholesterol biosynthesis program. Its dominant role over sterol regulatory element-binding protein 2 (SREBP2) renders TNBC highly vulnerable to RORγ inhibitors alone or in combination with statins. © 2020 Taylor & Francis Group, LLC.

Citation

Demin Cai, Xiong Zhang, Hong-Wu Chen. A master regulator of cholesterol biosynthesis constitutes a therapeutic liability of triple negative breast cancer. Molecular & cellular oncology. 2020;7(2):1701362

PMID: 32158915

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