The primary cilium: Its role as a tumor suppressor organelle.

Estanislao Peixoto, Seth Richard, Kishor Pant, Aalekhya Biswas, Sergio A Gradilone

Biochemical pharmacology 2020 May

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The primary cilium is an organelle that nearly all cells within the body contain. Its function is to sense the extracellular environment through its abundance of receptors and linked signaling pathways, working as an antenna. Ciliary defects lead to different pathologies. In particular, many tumors lose primary cilia, and this is linked with negative implications for the cell such as an increase in malignancy. In this work we will go through the knowledge of the role of primary cilia in normal conditions, how it is involved in diverse signaling pathways, and in disease, particularly in cancer, highlighting its tumor suppressor properties. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Estanislao Peixoto, Seth Richard, Kishor Pant, Aalekhya Biswas, Sergio A Gradilone. The primary cilium: Its role as a tumor suppressor organelle. Biochemical pharmacology. 2020 May;175:113906