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    Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (the principal mediators of atherosclerosis). Despite this, aggressive endothelial repair (progressing atherosclerosis) might cause a wasting reduction in CD34+ cells, which could result in a lower capacity of endothelial repair and hypertension. As yet, no prospective study has clarified the association of circulating CD34+ cells with active arterial wall thickening. We conducted a prospective study of 363 men aged 60-69 years who participated in a general health check-up at least twice from 2014-2017. The circulating CD34+ cell count was significantly positively associated with active arterial wall thickening among subjects without hypertension (nā€‰=ā€‰236), but not among subjects with hypertension (nā€‰=ā€‰127). The fully adjusted odds ratios (ORs) of active arterial wall thickening for the logarithmic circulating CD34+ cell count were 1.83 (1.19, 2.84) and 0.69 (0.36, 1.32) for subjects without and with hypertension, respectively. Circulating CD34+ cells are positively associated with active arterial wall thickening in subjects without hypertension. This study demonstrates a means to clarify the mechanisms of endothelial repair in elderly subjects.


    Yuji Shimizu, Shin-Ya Kawashiri, Kairi Kiyoura, Jun Koyamatsu, Shoichi Fukui, Mami Tamai, Kenichi Nobusue, Hirotomo Yamanashi, Yasuhiro Nagata, Takahiro Maeda. Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study. Scientific reports. 2020 Mar 13;10(1):4656

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    PMID: 32170211

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