FSH signaling is involved in affective disorders.

Wen-Kai Bi, Si-Si Luan, Jing Wang, Shan-Shan Wu, Xin-Chen Jin, Yi-Lin Fu, Ling Gao, Jia-Jun Zhao, Zhao He

Biochemical and biophysical research communications 2020 May 14

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Affective disorders are a set of mental disorders and particularly disrupt the mental health of susceptible women during puberty, pregnancy, parturition and menopause transition, which are characterized by dramatic changes in reproductive hormone profiles. The serum FSH level changes significantly during these periods; yet, the role of FSH in mood regulation is poorly understood. In the current study, FSHR knockout (Fshr-/-) mice displayed enhanced affective disorder behaviors in an open field test and a forced swim test, accompanied by altered gene expression profiles. The differentially expressed genes between Fshr-/- mice and Fshr+/+ mice were enriched in multiple neuroendocrine metabolic pathways. FSHR deletion significantly increased/decreased the mRNA and/or protein expression levels of AOX1, RDH12, HTR3a and HTR4 in mood-mediating brain regions, including the hippocampus and prefrontal cortex. These results reveal that FSH signaling is involved in the development of affective disorders. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Wen-Kai Bi, Si-Si Luan, Jing Wang, Shan-Shan Wu, Xin-Chen Jin, Yi-Lin Fu, Ling Gao, Jia-Jun Zhao, Zhao He. FSH signaling is involved in affective disorders. Biochemical and biophysical research communications. 2020 May 14;525(4):915-920