Shelterin and the replisome: at the intersection of telomere repair and replication.

Alessandro Cicconi, Sandy Chang

Current opinion in genetics & development 2020 Feb

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Telomeres are G-rich repetitive sequences that are difficult to replicate, resulting in increased replication stress that can threaten genome stability. Shelterin protects telomeres from engaging in aberrant DNA repair and dictates the choice of DNA repair pathway at dysfunctional telomeres. Recently, shelterin has been shown to participate in telomere replication. Here we review the most recent discoveries documenting the mechanisms by which shelterin represses DNA repair pathways at telomeres while assisting its replication. The interplay between shelterin and the replisome complex highlights a novel connection between telomere maintenance and repair. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Alessandro Cicconi, Sandy Chang. Shelterin and the replisome: at the intersection of telomere repair and replication. Current opinion in genetics & development. 2020 Feb;60:77-84