Video analysis of long-term effects of levodopa-carbidopa intestinal gel on gait and posture in advanced Parkinson's disease.

Margherita Fabbri, Chatkaew Pongmala, Carlo Alberto Artusi, Gabriele Imbalzano, Alberto Romagnolo, Leonardo Lopiano, Maurizio Zibetti

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2020 Jul

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Gait and posture parameters of ten advanced Parkinson's disease (PD) patients were assessed before and after starting levodopa-carbidopa intestinal gel (LCIG) treatment by means of both objective video analysis and clinical assessment. After 3 years of treatment, gait and posture remained stable. A slower gait velocity at baseline significantly correlates with a higher axial and motor severity at follow-up. This pilot study suggests that validated video analysis software may support the clinical assessment of axial signs in PD patients who are candidates for device-aided therapies.

Citation

Margherita Fabbri, Chatkaew Pongmala, Carlo Alberto Artusi, Gabriele Imbalzano, Alberto Romagnolo, Leonardo Lopiano, Maurizio Zibetti. Video analysis of long-term effects of levodopa-carbidopa intestinal gel on gait and posture in advanced Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2020 Jul;41(7):1927-1930