Extracellular vesicles in normal pregnancy and pregnancy-related diseases.

Jiayin Zhang, Haibo Li, Boyue Fan, Wenrong Xu, Xu Zhang

Journal of cellular and molecular medicine 2020 Apr

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Extracellular vesicles (EVs) are nanosized, membranous vesicles released by almost all types of cells. Extracellular vesicles can be classified into distinct subtypes according to their sizes, origins and functions. Extracellular vesicles play important roles in intercellular communication through the transfer of a wide spectrum of bioactive molecules, contributing to the regulation of diverse physiological and pathological processes. Recently, it has been established that EVs mediate foetal-maternal communication across gestation. Abnormal changes in EVs have been reported to be critically involved in pregnancy-related diseases. Moreover, EVs have shown great potential to serve as biomarkers for the diagnosis of pregnancy-related diseases. In this review, we discussed about the roles of EVs in normal pregnancy and how changes in EVs led to complicated pregnancy with an emphasis on their values in predicting and monitoring of pregnancy-related diseases. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Citation

Jiayin Zhang, Haibo Li, Boyue Fan, Wenrong Xu, Xu Zhang. Extracellular vesicles in normal pregnancy and pregnancy-related diseases. Journal of cellular and molecular medicine. 2020 Apr;24(8):4377-4388