Involvement of calcium channels in the regulation of adipogenesis.

Mingzhu Zhai, Dazhi Yang, Weihong Yi, Wuping Sun

Adipocyte 2020 Dec

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As an important second messenger in adipocytes, calcium ions (Ca2+) are essential in regulating various intracellular signalling pathways that control critical cellular functions. Calcium channels show selective permeability to Ca2+ and facilitate Ca2+ entry into the cytoplasm, which are normally located in the plasmatic and intracellular membranes. The increase of cytosolic Ca2+ modulates a variety of signalling pathways and results in the transcription of target genes that contribute to adipogenesis, a key cellular event includes proliferation and differentiation of adipocyte. In the past decades, the involvement of some Ca2+-permeable ion channels, such as Ca2+ release-activated Ca2+ channels, transient receptor potential channels, voltage-gated calcium channels and others, in adipogenesis has been extensively explored. In the present review, we provided a summary of the expression and contributions of these Ca2+-permeable channels in mediating Ca2+ influxes that drive adipogenesis. Moreover, we discussed their potentials as future therapeutic targets.

Citation

Mingzhu Zhai, Dazhi Yang, Weihong Yi, Wuping Sun. Involvement of calcium channels in the regulation of adipogenesis. Adipocyte. 2020 Dec;9(1):132-141