FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles.

International journal of molecular sciences 2020 Mar 12

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Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.

Citation

Franz L Ricklefs, Cecile L Maire, Jakob Matschke, Lasse Dührsen, Thomas Sauvigny, Mareike Holz, Katharina Kolbe, Sven Peine, Christel Herold-Mende, Bob Carter, E Antonio Chiocca, Sean E Lawler, Manfred Westphal, Katrin Lamszus. FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. International journal of molecular sciences. 2020 Mar 12;21(6)